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by Marijana Domazet, Thursday, 11 July 2013 | Categories: Diet Pills

A large number of studies, both in humans and in animals, have looked at the mechanisms required for white adipose tissue to work as brown adipose tissue. However, until recently we were not aware of any studies that had considered whether there were any treatments that could affect this process. Now, a team of researchers is suggesting that a drug that is being trialled for thyroid treatment may be useful in this process.

It is commonly known that humans have two types of adipose tissue, brown adipose tissue and white adipose tissue. Whilst the former helps to protect against obesity, the latter contributes to it. Essentially, brown adipose tissue works more efficiently than white adipose tissue at burning energy. The faster energy burning in brown adipose tissue has been attributed to a process called thermogenesis. As such it should come as little surprise that researchers would be keen to find a way to exploit the potential relationship between thermogenesis and treatments.

The current findings were presented at The Endocrine Society's 95th Annual Meeting, and are yet to be published. The researchers used an experimental drug that goes under the name of GC-01 in obese mice and found that it increased their metabolism by more than 60%, which also led to significant weight loss. Based on this, the researchers concluded that CG-01 could be useful in inducing thermogenesis in white adipose tissue, which in turn would aid fat being converted into energy.

Although these findings are intriguing, the presentation raises more questions than answers. There are several aspects of the current report that need to be put into perspective. For instance, the finding that it increased metabolism by 60 % may change once it is put into perspective in terms of what it means statistically. Similarly, these 60% are likely to refer to beiging of white adipose tissue, which has a small effect on making white adipose tissue work like brown adipose tissue. It does not imply that white adipose tissue starts to work completely like brown adipose tissue.





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