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by Marijana Domazet, Tuesday, 01 July 2014 | Categories: Viagra

Whilst it is well known that medicinal research focuses on considering the same treatment for multiple conditions, the other side of the coin is that some research also considers whether certain medications can cause or trigger other illnesses.

An example of the latter comes from a recent study considering the relationship between melanoma and the use of Viagra. The somewhat surprising relationship has gained attention from the research community.

The study, which was published in JAMA Internal Medicine, was a prospective cohort study. It included a total of 25,848 participants with an average age of 65. The participants completed a questionnaire every two years. The results from the questionnaire were then compared with the diagnosis of melanoma within this group. The main findings indicated that men who were using or had used Viagra had a higher risk of developing melanoma. Specifically, a history of using Viagra was linked to a man being twice as likely to develop melanoma, whereas using Viagra increased the risk by 84%. The researchers concluded that more research is needed to establish the reason for this relationship before any clinical recommendations are enforced.

We agree with the researchers that more studies are needed to fully grasp any implications of the findings. Whilst the study demonstrates interesting findings, they are still yet to be replicated and understood. Many studies find links between certain variables however it may be spurious or altogether irrelevant for the aetiology of an illness. In addition to that, it is worth highlighting that much of the data came from self-reported questionnaires, which may not be the most reliable measurement.

Despite this, some physicians have suggested that medical practitioners enquire whether patients who use Viagra have experienced a change in their skin. Although it never hurts to be too cautious when treating patients, perhaps it is premature to suggest additional checks as a result of one observational study.

Given that melanoma has been on the decrease over the period that Viagra has been around, we cannot see an argument for correlation, far less causality. You can read more information on this study at this website.




The use of old medications for new treatment is one of the most common occurrences in medical research and is a topic we have covered many times before. Generally, the illnesses tend to reflect a joint underlying mechanism that can be exploited using similar treatments. The most recent version of this comes from a controversial new study, which will aim to treat pre-eclampsia with sildenafil.

Pre-eclampsia is a disorder that affects a number of pregnant women per year and results in an estimated 600 still births per year in the UK. One of the key aspects of the disorder is that the unborn infant often does not receive all the blood that it needs as the arteries that feed the placenta fail to widen. As a result of this, many of those infants are either still born or born prematurely. It is believed that a moderate dose of sildenafil could aid in widening the arteries, thereby helping the placenta to widen. However, in order for this to be considered as a valid treatment, multiple clinical trials are needed. As such, it should come as no surprise that two trials in New Zealand and UK are underway.

The largest trial, which will be carried out in New Zealand, is aiming to recruit 120 women. The participants will be given either a placebo or a controlled dose of sildenafil citrate (also known as a generic version of Viagra). The researchers are hoping that the results will mimic findings from previous animal studies, where sildenafil citrate aided increased blood supply to the placenta. It is hoped that the results and analyses will be complete by 2017. Currently, there is not any information provided about the trial in the UK.

Although we can understand the rationale for the trials, there are a few areas that we hope the researchers will clarify. Perhaps the most obvious aspect comes from the associated long and short term risks for women and their infants that have not been made clear in the information released to date. Similarly, we would be keen to understand how long the women would be followed up, and what instruments would be used for assessments and comparisons between the groups.

Although there are questions raised, it is clear that this research may open up a new avenue of treatment that could affect many lives. This, if anything, is cause for optimism.




by Robert MacKay, Friday, 21 June 2013 | Categories: Erectile Dysfunction | Viagra

The patent for Sildenafil expires today so generic versions of Viagra can be prescribed in the UK for the first time. The plethora of new products containing Sildenafil as the active ingredient has led to a massive reduction in prices. The price of branded Viagra will remain unchanged but the new products are available at very low competitive prices. Pfizer has come out with its own generic version of Sildenafil that is white rather than the famous blue branded version and is approximately half the price.

The Online Clinic is now offering to prescribe licensed generic versions of Sildenafil for a fraction of the cost of the branded version. We have a minimum private prescription charge of £29.95 (which includes the private prescription, a box of medication and guaranteed next day delivery). With discounts for larger quantities, the price per pill falls dramatically. We are so confident that our prices represent excellent value for money that we have a price match policy if you see the same service cheaper elsewhere through an appropriately licensed provider.

If you are already approved for erectile dysfunction products through The Online Clinic then you just need to login to your account and update your medical details and we will automatically add the new products. If you are new to The Online Clinic, simply click on the free consultation button below to begin.

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by Marijana Domazet, Sunday, 12 May 2013 | Categories: Viagra

Almost everyone who has been inundated with spam emails advertising the possibility to buy cheap Viagra online is well aware of how large the black market for selling counterfeit Viagra is. This market has been seemingly unaffected by numerous studies demonstrating the risks associated with these pills such as the fact that they often contain hazardous contaminants. Although we have provided prescriptions and the possibility to buy this treatment online in various countries, it has not been possible to do the same in the US. In an attempt to address these issues, Pfizer has aligned with a pharmacy to offer patients the possibility to buy Viagra online in the US for people who have a valid US prescription.

Earlier this week, the pharmaceutical company announced that patients would be able to purchase Viagra online, as well as refill existing prescriptions, check the status of their order and estimate insurance co-payments. In order to do so, it is essential that patients visit a doctor in a face-to-face environment to obtain a prescription. Naturally, the tablets will be more expensive than the counterfeits offered online. However, they will be safe and save patients the potential embarrassment of going to a pharmacy to get their treatment

We have been following the research and trends related to Pfizer for a long time, and can see that this development is long overdue. For instance, about two years ago, Pfizer published a study whereby they had analysed the chemical contents of counterfeit pills that had been sold online. They did so by purchasing treatments from the top 22 websites that came up following a search on the words “buy Viagra online”. The startling findings indicated that counterfeit treatments contained pesticides, commercial paint, printer ink and wallboard. In addition to that, 80% of the pills contained 30-50% less sildenafil (the active ingredient) than was advertised.

It is important to note that this development is only occurring in the US, and as such is not applicable to European countries. However, we would like to stress the importance of being safe with purchasing erectile dysfunction treatments online. For us, the safety of our patients cannot be understated and this is why we have taken so many pre-cautions to ensure that our patients are suitable for treatment and only supply them from a registered pharmacy. We understand that there may be many reasons for wishing to purchase a treatment online, and would urge anyone in this situation to research a website before making any purchases. The general rule is that you should only buy from a website that is either registered with the General Pharmaceutical Council or licensed by the Care Quality Commission.




by Robert MacKay, Sunday, 17 March 2013 | Categories: Viagra

The importance of being informed about potential side effects of any medication cannot be understated. However, when new medications come out there is always a possibility that reports of side effects unknown to the pharmaceutical companies and researchers emerge in the post marketing environment. But sometimes there are reports of potential side effects that only affect a few people and these should not necessarily be construed as a having widespread applicability. A few incidents of blindness following Viagra use have been reported in the United States but what is the validity of the claim?

It is commonly known that transient visual disturbances can occur as a result of taking Viagra. However, these side effects are noted on the rarer end of the scale and appear to occur in 4% of the study participants. It has been argued that this is due to that fact that sildenafil, the active ingredient in Viagra, partially blocks an enzyme called PDE6, which is known to mediate the process of transduction. Reviews and meta-analyses of clinical studies suggest that these side effects can be lessened with appropriate dosage adjustment and animal studies indicate that sildenafil does not have any major effect upon a normal retina. Moreover, long-term toxicology studies to date do not demonstrate any adverse visual side effects upon normal retinae. There is little possibility that such a large number of studies that have systematically investigated the drug would have such low quality or be unreliable.

Having said that, we understand that there have been 50 lawsuits against Pfizer (the manufacturer of Viagra) where individuals have claimed to have lost their sight as a result of using Viagra. However, on examination most of these men had type 2 diabetes, which is widely known to cause blindness. We need to also consider these 50 cases within the context of over 23 million men having been prescribed Viagra globally without similar side effects.

There are certain medical conditions related to vision which definitely contraindicate patients for Viagra. For example, we would never prescribe for any patient who had retinitis pigmentosa or macular degeneration. However, we are confident that sildenafil does not cause blindness. The men in the US who have experienced blindness probably have their type 2 diabetes to blame and that in turn can be blamed on their bad lifestyle choices over the years. It is important not to have a closed mind, but Viagra really is one of the safest medications around.

More information can be read about Viagra and visual disturbances here.




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