Mysimba Prices from £139.95


What is Mysimba?

Mysimba is a weight loss medication available in the UK that has been developed by Orexigen Therapeutics in the US. The same medication is available as Contrave in the USA.

Mysimba contains Bupropion and Naltrexone as the active ingredients.

The Mysimba diet pill affects how the brain and central nervous system regulate appetite, food cravings, energy expenditure and, in turn, body weight.

Can I buy Mysimba online?

Mysimba is available through The Online Clinic. Please complete a free consultation so you can be assessed by one of our doctors.

Free Online Assessment Quick and Without Obligation

How does Mysimba work?

Orexigen says that their research indicates that the combination of Bupropion and Naltrexone, which treats addictive disorders such as alcohol abuse, works to improve the body's ability to initiate weight loss and continues this process by blocking the body's usual attempts to compensate for the weight loss during treatment.

Bupropion is believed to increase levels of activity of the neurotransmitter dopamine in the brain, which reduces appetite and encourages the body to use more energy. Naltrexone, as well as ensuring the weight loss continues, also makes certain foods (especially sweet things) taste less palatable.

Previously, scientists had noted that patients taking Bupropion for depression also lost weight, but this effect tended to stop after a period taking the drug. Orexigen hypothesized that by combining Bupropion with Naltrexone, the weight loss would continue throughout the duration of the treatment. This appears to have been borne out in clinical trials.

How effective is Mysimba?

Four different Phase 3 clinical trials have been run for Mysimba. Here are the notable results in terms of efficacy:

  • 50.8% of Mysimba users lost more than 5% of their bodyweight at Week 16.
  • At one year, the average weight loss amongst these Week 16 responders was 11.3%
  • 55% of Week 16 responders lost more than 10% bodyweight after one year.

Are there other benefits associated with Mysimba?

In addition to the loss of weight, there were a number of additional benefits attributed to taking Mysimba, such as a reduction in waist circumference and therefore a reduction in the dangerous visceral fat that collects around the middle and is a risk factor for diabetes and cardiovascular problems. There was also a reduction in LDL cholesterol (the bad form of cholesterol) and triglycerides. Improvements in glycaemic control were also observed in diabetic patients.

Mysimba Side Effects

As with all medications, some side effects were noted. Here are the most common side effects:

  • Anxiety
  • Insomnia
  • Headache
  • Restlessness
  • Dizziness
  • Concentration disturbance
  • Palpitations
  • Hot flush
  • Nausea
  • Constipation
  • Muscular pain

It should be noted that most patients did not get any side effects but all side effects should be reported to the prescribing doctor in case it is appropriate to recommend cessation of treatment.

Blood pressure should be monitored regularly while undergoing treatment with Mysimba.

You can read more about Mysimba here.

Reviewed by: Dr Loraine Haslam MBBS, DRCOG, DFSRH, LoC SDI, LoC IUT, MRCGP
GMC registration number: 4524038
Date: 12 August 2022
Next review: 11 August 2023
All UK registered doctors can have their registration checked on
The Medical Register at the GMC website.

Information Leaflet

Source and further information

Mysimba Reviews By Our Patients

  • Overall Rating
    Based on 14 reviews
  • ★★★☆☆
    A. F. - 12/02/20
  • ★★★★☆
    works pretty good for a while then seems to wear off once body gets used to it.
    J. B. - 18/01/20
  • ★★★★★
    First class professional service. No faults just all positives.
    G. W. - 12/07/23
  • ★★★★☆
    Not long after ordering, my brother passed away and so I was not taking it properly/ regularly enough. Sadly, I am a month in and have actually gained a couple of pounds. I know it takes time to start working so I will persevere, but I am hoping to switch to an injection based medicine instead when they are available.
    N. B. - 05/09/23
  • ★☆☆☆☆
    The Online Clinic were very helpful and professional regarding my prescription of mysimba. It arrived quickly and discreetly. However, after a week of using mysimba I felt rather low in mood and it increased my appetite and cravings. After the second week I felt suicidal ??. I contacted The Online Clinic who responded immediately and advised to stop taking them as this is sometimes a severe side effect of mysimba. They were very supportive and checked up on my mental health with messages, however it's a lot of money to pay to find out that t...
    DT - 15/01/20
  • ★☆☆☆☆
    I’ve had an allergic reaction to buphrion - hyperpigmentation on the skin around my neck. My dermatologist has advised me to discontinue the medication. Please can I ask if you have an alternate medication you can recommend?
    S. S. - 26/09/23
  • ★★★★★
    It helps me a lot
    E. M. - 08/03/22
  • ★★★★☆
    It’s really helping with my appetite
    D. E. - 15/08/20
  • ★★★★☆
    Very pleased with the process of my order. Arrived quickly. I was a bit apprehensive about ordering mysimba as some reviews stated their side effects such as sickness but I've so far used these for nearly a week and no sickness. Ive been using these for a week And feel pretty good. It doesnt stop craving for treats so I need to pull out the will power but I have exercised and feeling good about trying harder to lose weight. Lets see how next week goes.
    R. H. - 04/10/20
  • ★★★★★
    As the reviews say don't quite understand how this product works, but it does - at least for me. Adding it to my exercise and diet has helped me lose an additional 7 lbs under the first regiment and am hoping for another 7 - 10 on the next. Maybe for the first time in decades my BMI will get to below morbidly obese
    M. S. - 30/09/20
  • ★★★★★
    I had a bit of nausea to begin with but this product totally cut my appetite and I have lost weight. I would definitively recommend Mysimba.
    Oli M. - 18/12/19
  • ★★★★★
    very pleased indeed - does exactly what i was seeking - lost 10lbs
    S. W. - 10/04/21
  • ★☆☆☆☆
    It never worked
    G. S. - 09/06/23
  • ★★★★☆
    Excellent! This has certainly helped me!
    Anonymous - 12/12/19

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