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H. pylori

Can I get a test and treatment for H. Pylori online?

The Online Clinic can perform an assessment online free of charge and prescribe treatment if you have had a positive test result for H. pylori.

Free Online Assessment Quick and Without Obligation

If you have not had a positive test result, we can provide a postal test, with results in 2 days. To order this, add the test below to your basket.

H. Pylori test kit £79.95
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What is H. pylori?

Helicobacter pylori, abbreviated to H. pylori, is a bacterium found in the stomach. Infection is thought to occur through mouth-to-mouth contact or consumption via hands, food or water contaminated with stools. The bacteria enter the stomach lining, causing the release of agents that activate the body's immune system. This leads to inflammation of the linings of the stomach (gastritis) or of the duodenum (part of the gut attached to the stomach; duodenitis), which makes the stomach and duodenum susceptible to further attack from stomach acid and digestive juices.

Signs and symptoms

Signs and symptoms will indicate the need for testing for H. pylori. Most people with this infection have no symptoms and do not develop problems. However, the bacteria can cause gut problems, such as gastritis/duodenitis and peptic ulcers in the stomach or duodenum. Symptoms include pain or discomfort, bloating, poor appetite, nausea/vomiting, anaemia, and blood in stool or dark-coloured stools. H. pylori is regarded as an important risk factor for stomach cancer, as a result of abnormal changes in the stomach lining caused by long-term gastritis.

Testing for H. pylori

There are several tests for the detection and diagnosis of an H. pylori infection, which can be invasive (based on a procedure known as endoscopy) or non-invasive. Testing is not usually carried out in people with no symptoms, no previous peptic ulcer disease, and no active ulcers.

The most widely used non-invasive tests are the stool antigen test and the breath test. Stool antigen tests detect H. pylori proteins in a stool sample. These proteins act as antigens, i.e., substances that are alien to the body. The body's normal response by its immune (defence) system to an antigen is to produce antibodies to bind with, and thus counteract, the antigen. Stool tests use antibodies to bind with specific antigens, enabling the antigen-antibody complexes to be detected by a colour change in the prepared stool sample. This simple test can be used for both diagnosis and monitoring after treatment. As a stool sample only is required, the method is especially useful for children.

Breath tests, called urea breath tests, require patients to swallow a solution containing urea labelled with carbon-13 or carbon-14. If present, H. pylori uses the enzyme urease to convert urea to labelled carbon dioxide in the stomach. Labelled carbon dioxide then passes into the blood where it is transported to the lungs and can be detected in exhaled breath using special laboratory equipment.

Blood tests are based on the detection of antibodies produced by the body's immune system in response to the bacteria. Blood tests are only of use if the person has not previously received treatment for this infection.

Endoscopy involves insertion, through the mouth and into the stomach/duodenum, of a hollow tube with a light and camera at the end. Examination of the images projected onto a screen can be used to detect any abnormalities, such as gastritis and ulcers. Tools can be inserted down the tube enabling collection of tissue samples for further testing.

Testing for H. pylori at The Online Clinic

The Online Clinic uses a stool antigen test. This is the most appropriate diagnostic test for H. pylori when the patient is not attending in person. The test will allow us to determine if you have an active H. pylori infection.

The stool sample is collected using a kit designed for patients to use at home. The kit comes with full instructions. The sample is sent back to our laboratory in a reply-paid tracked envelope, which usually arrives the day after it is posted.

You must not use this test if you have taken antibiotics in the previous 4 weeks, or if you have used a Proton Pump Inhibitor (such as Omeprazole) in the previous 2 weeks. If you have used an H2-receptor antagonist (such as Famotidine), then you need a gap of 4 days before providing your stool sample.

Results from this test are usually available within 2 days of the sample arriving in the laboratory. You are provided with the lab report and a doctor's interpretation.

Treatment of H. pylori

Generally, people with an H. pylori infection who do not have symptoms will not be treated; those who have symptoms, previously had peptic ulcer disease, or have active gastric or duodenal ulcers should be treated.

Treatment is based on antibiotics that kill the bacteria combined with an antisecretory medicine that reduces the production of stomach acid (and so prevents gastritis and ulcer formation) and enables damaged tissues to heal. Reducing the acidity in the stomach is necessary for the antibiotics to work effectively.

Commonly, the treatment strategy is triple therapy, as three drugs are used. Two different antibiotics are used; clarithromycin (or metronidazole in clarithromycin resistant strains) and amoxicillin (or metronidazole in cases with penicillin allergy) as well as a proton pump inhibitor (PPI; e.g., esomeprazole lansoprazole, and omeprazole) which reduces the amount of acid the stomach makes. Treatment is for 7 days.

Treatment failure, which potentially results in antibiotic resistance, is potentially lowered by using two antibiotics. A test of cure after treatment will confirm clearance of the infection. People who still have an H. pylori infection may need further treatment using different antibiotics. Antibiotic resistance is of growing concern; thus, it is very important that all the medicines are taken as prescribed and that the individual has a follow-up test.

Reviewed by: Dr Loraine Haslam MBBS, DRCOG, DFSRH, LoC SDI, LoC IUT, MRCGP
GMC registration number: 4524038
Date: 17 August 2022
Next review: 16 August 2024
All UK registered doctors can have their registration checked on
The Medical Register at the GMC website.
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