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Syncrodin is used for the treatment of jet lag.

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What is Syncrodin?

Syncrodin is a tablet containing 3 milligrams of melatonin. It is used in the treatment of jet lag, which manifests as sleep disturbances, tiredness during the day, irritability, problems with concentration and memory, and gut problems after traveling long distances in an aircraft.

Each person has an internal 'body clock' that controls their natural 24-hour body rhythm (known as the circadian rhythm). This is influenced by the hours of daylight and night-time darkness occurring every 24 hours in the area where they live. Each country location is in a 'time zone', meaning that time zones are often crossed when travelling east or west to another country. Jet lag occurs when the different time zone at the destination disturbs the body's usual day-night rhythm. The symptoms and severity of jet lag tend to be worse and longer lasting the more time zones that are crossed.

Melatonin is involved with the timing of body rhythms such as sleep. It has a sedative effect and increases natural tendency for sleep. Melatonin is a hormone produced by the pineal gland in the brain in response to light received by the retina in the eye. Melatonin levels rise as daylight fades towards the darkness of night, peak during the dark, and then fall with increasing daylight exposure. Syncrodin helps to re-establish the body's normal day-night rhythm; it alleviates the symptoms and reduces the severity of jet lag.

How to use Syncrodin

Take Syncrodin tablets exactly as your doctor has described. Generally, one Syncrodin 3 mg tablet is taken each day for a maximum of 5 days. Two 3 mg tablets can be taken if one tablet does not sufficiently relieve the symptoms. The first Syncrodin dose should be taken when arriving at your destination, at the time you usually go to bed; this time should not be before 20:00 hours or after 04:00 hours at your destination. Also take Syncrodin at the time you usually go to bed on the following days. You can be treated with Syncrodin for a maximum of 5 days, on 16 or fewer occasions a year.

Tablets must be swallowed whole (not broken or chewed) with water or fluid, and food should not be eaten either 2 hours before or 2 hours after taking the tablet(s) as food can alter melatonin levels in the blood. Additionally, consuming alcohol is not recommended, as it not only impairs sleep but may worsen some symptoms of jet-lag such as morning tiredness and concentration.

Contact your doctor if you have taken too much Syncrodin and do not feel well. If you forget your bedtime dose, you may take the tablet(s) if you wake during the night but only if it is before 04:00 hours.

Who can use Syncrodin?

Syncrodin is for use by adults and elderly persons. It is not recommended in women during pregnancy or breast-feeding, or women of childbearing age who are not using contraception.

Syncrodin must not be taken by anyone who is allergic to any of the ingredients of this medicine including melatonin. Before taking Syncrodin, a consultation is required. Please provide as much information as possible, particularly if you have epilepsy (melatonin may increase the frequency of seizures), diabetes/impaired glucose tolerance (melatonin may increase blood glucose level), an autoimmune disease (melatonin may worsen the condition), problems with liver or kidney function (melatonin is broken down in the liver and excreted by the kidneys via urine), or if you smoke (constituents of tobacco smoke may increase the rate melatonin is broken down, thereby reducing blood melatonin levels).

Your doctors will also want to know the medicines that you have recently taken, are taking, or might take. This is because some medicines increase the effect of melatonin, including cimetidine (treats stomach problems), fluvoxamine (treats depression, obsessive-compulsive disorder), oestrogens (contraceptives, hormone replacement therapy), psoralens (treats skin disorders), and quinolones (treats bacterial infections). The sedative effect of benzodiazepines (such as midazolam, temazepam) and non-benzodiazepine hypnotics (like zaleplon, zopiclone, zolpidem), and some of zolpidem's side effects (including morning sleepiness, confusion, nausea), can also be increased by melatonin. On the other hand, some medicines decrease the effect of melatonin, including carbamazepine (treats epilepsy), and rifampicin (treats bacterial infections).

Syncrodin should not be used before driving or using machines because it may reduce alertness and cause drowsiness.

Syncrodin side effects

As with all medications, Syncrodin can cause side effects but these are rare or uncommon. The principal side effects noted are joint stiffness, pain and increased risk of infection.

Reviewed by: Dr Loraine Haslam MBBS, DRCOG, DFSRH, LoC SDI, LoC IUT, MRCGP
GMC registration number: 4524038
Date: 30 October 2023
Next review: 29 October 2025
All UK registered doctors can have their registration checked on
The Medical Register at the GMC website.

Information Leaflet

Source and further information

Syncrodin Reviews By Our Patients

  • Overall Rating
    Based on 1 review
  • ★★★★★
    Very helpful
    C. B. - 05/01/24
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