UK Registered DoctorsPLAC (Lp-PLA2) Test
What is Lp-PLA2?
Lp-PLA2 stands for lipoprotein-associated phospholipase A2. Lp-PLA2 is an enzyme that is produced by inflammatory cells. Lp-PLA2 binds to lipoproteins (fat +protein) such as low- density lipoprotein (LDL or “bad” cholesterol) in the blood. It accumulates in artery walls, where it stimulates inflammatory disease processes, the production of more Lp-PLA2, and the development of plaque. The plaque size and of its overlying cap thickness determine the plaque’s instability. The build-up of plaque (fats and other substances) within and on the arterial walls is a key factor in the development of atherosclerosis and cardiovascular disease.
What is a PLAC (Lp-PLA2) Test?
The PLAC (Lp-PLA2) test measures the level of the enzyme Lp-PLA2 produced by the arterial plaque and present in the blood. Specifically, the test provides an indication of inflammation in the arteries and the build-up of plaque.
Can I buy the PLAC (Lp-PLA2) Test online?
The Online Clinic can organise this test as either a self-collect sample using a specially designed kit for patients to use at home or via a professionally collected blood sample from a vein at one of our partner pharmacies. The home test kit is very easy to use, with the small blood sample sent back to our lab using a tracked service that is included in the price.
Why is a PLAC (Lp-PLA2) Test important?
Lp-PLA2 indicates the amount of inflammation and plaque in the arteries, and the development of atherosclerosis. The Lp-PLA2 test is important because with growth of the plaque, the artery becomes narrower. This arterial narrowing starts to, and will eventually completely, block the artery, preventing the normal flow of blood. Additionally, the plaque’s cap can rupture, whereby plaque fragments are released into the bloodstream, leading to blood clots. The blood clots restrict or prevent blood flow, and lead to cardiovascular events, including heart attack and stroke.
The Lp-PLA2 test can be used to assess the risk of cardiovascular events in people with raised cholesterol levels, and in people with normal cholesterol levels but with arterial plaque build-up. It can also identify plaque that is likely to rupture.
Who should have a PLAC (Lp-PLA2) test?
A Lp-PLA2 test is usually recommended for individuals who are at high risk of cardiovascular disease, such as those with high or raised cholesterol, high blood pressure, diabetes, or who have a family history of cardiovascular disease. Additionally, a test may be suggested for people with negative lifestyle factors, including an unhealthy diet, lack of physical exercise, excessive alcohol consumption, or who are smokers or former smokers.
How to test for PLAC (Lp-PLA2)?
Testing for Lp-PLA2 requires a small sample of blood. The blood sample is collected at home using the test kit and following the simple instructions provided. The process involves pricking your little finger tip with a lancet, and collecting several blood drops up to the top line on the side of the collection tube. The other little finger tip is used if more blood is needed for the full blood sample. After sealing the collection tube with its cap, the tube is gently inverted five to ten times. All labels must be completed before the collection tube is packed for posting as per the instructions.
The PLAC (Lp-PLA2) test results are sent to a doctor at The Online Clinic, who will explain them to you and consider if you need more tests or treatment.
How do I get my results from the PLAC test?
One of the doctors at The Online Clinic will interpret your result and publish it on your Patient Dashboard with an explanation. The full lab report is also provided as a PDF so you can download and send it to another healthcare provider if required.
What do PLAC (Lp-PLA2) Test results indicate?
The PLAC (Lp-PLA2) test result will determine if you have an increased risk of cardiovascular disease. The test provides more information than a test for cholesterol only. High levels of Lp-PLA2 indicate that there is inflammation in the arteries, which suggests that there is an increased risk of heart attack and stroke.
The PLAC (Lp-PLA2) test should not be the only test used to evaluate your cardiovascular risk. Your test results and what they mean should also be explained to you by your healthcare professional. Such practices minimise the chances of subsequent over- or under- testing or treatment for cardiovascular disease.
